CFSBDr Clair-Florent Schmitt-BernardOphthalmic surgeonContact

Professional and scientific profile

Profile

Portrait of Dr Clair-Florent Schmitt-Bernard
01

Credentials and career

Professional, scientific and university-hospital career

University education

  • Master’s degree in Biological and Medical Sciences · Montpellier I University, 1994–1995
  • Doctor of Medicine · Montpellier I University, 1996
  • Specialist qualification in ophthalmology · 1996
  • Qualification listed in the English CV as “Physical Degree” · Montpellier I University, 1996
  • Postgraduate diploma in Health Biology · Montpellier I University, 1997
  • PhD in Science · Montpellier I University, 2001

University-hospital career

  • Ophthalmology residency · Montpellier, 1991–1995; Paris, 1995–1996
  • Hospital assistant in ophthalmology · Montpellier University Hospital, 1997–2001
  • National hospital-practitioner examination in ophthalmology · ranked first, 1999
  • Referral physician for corneal transplantation · Montpellier University Hospital, 1997–2002
  • Member of the medical and technical tissue-preservation committee · Montpellier University Hospital, 1998–2002

Professional practice and affiliations

  • Antigone Ophtalmologie · 2002–2026
  • Surgical practice at Clinique Saint-Jean · 2002–2004
  • Surgical practice at Polyclinique Saint-Roch · 2004–2022
  • Co-founder of Clinique de la Vision Montpellier · 2012
  • President of Clinique de la Vision Montpellier · 2012–2018
  • Consultant ophthalmologist at Clinique de la Vision since 2012
  • Project to create the Occitanie Cornea and Keratoconus Centre in Montpellier · listed as ongoing in the supplied CV
  • Member of SAFIR · affiliation declared by Dr Schmitt-Bernard

Medical and surgical activities described in the CV

  • Specular microscopy and videokeratography; management of anterior-segment disorders, including hereditary and acquired corneal, conjunctival, refractive and glaucomatous conditions
  • Retinal investigation and treatment using angiography and laser · historical activity listed in the CV and not presented as a current area of practice on this website
  • Anterior-segment surgery and corneal emergencies, including the use of biosynthetic and biocompatible materials
  • Corneal transplantation and development of graft techniques: limbal autografts and allografts, lamellar keratoplasty and amniotic membranes
  • Corneal prosthetic surgery and biointegrable keratoprostheses
  • Lens implantation: suturable, injectable and iris-fixated implants
  • Refractive surgery for congenital and induced optical abnormalities
  • Keratoconus treatment: intracorneal rings, Topolink and cross-linking

Clinical and tissue developments

  • Contributed to development of the Montpellier University Hospital corneal bank using organ culture at +31 °C
  • Contributed to development of corneal retrieval in the forensic unit
  • Contributed to the Languedoc-Roussillon corneal-retrieval network with the Établissement français des Greffes
  • Development of videokeratography-guided refractive and therapeutic corneal surgery
  • Development of automated lamellar corneal surgery

Clinical research

  • Corneal-tissue preservation and endothelial-cell apoptosis · collaboration with the forensic-medicine department of Montpellier University Hospital, listed as ongoing in the CV
  • Cancer and corneal transplantation · multicentre study with Besançon University Hospital, listed as ongoing in the CV
  • Ocular fungal infections · multicentre study, parasitology laboratory, Montpellier University Hospital, 1998–2000
  • Clinical, genetic, immunohistological and ultrastructural analysis of families with hereditary TGFBI / BIGH3-associated corneal dystrophy · medical thesis supervision, listed as ongoing in the CV
  • Residual astigmatism after penetrating keratoplasty · 42 cases, medical thesis supervision, April 2000
  • Videokeratographic analysis of keratoconus inheritance in 12 families · prospective study and medical thesis supervision, November 2000
  • Value of interferometric analysis before cataract surgery and comparison of two methods · prospective study and medical thesis supervision, December 2000

Fundamental and doctoral research

  • Science thesis: genetic and structural characterisation of TGFBI / BIGH3-associated amyloid corneal dystrophies and the role of the Arg124 mutation in amyloid conversion
  • Collaborations with the molecular-biology laboratory of Montpellier University Hospital, the Structural Biochemistry Centre of Montpellier I University, the CNRS Macromolecular Biochemistry Research Centre and the Montpellier Regional Clinical Imaging Centre
  • Technical training: RT-PCR, PCR, SSCP, sequencing and mutation detection, linkage studies and Southern blot
  • Protein and peptide biochemistry; structural analysis of proteins
  • Histology, immunohistochemistry, scanning and transmission electron microscopy
  • Genetic, histological, immunohistochemical and ultrastructural characterisation of type I granular corneal dystrophy and Reis-Bücklers dystrophy · listed as ongoing in the CV
  • Therapeutic development in type I amyloid corneal dystrophy · listed as ongoing in the CV

Research awards and funding

  • French Federation for Blind and Visually Impaired People award · October 1999
  • University doctoral grant · SOS Rétinite Pigmentaire association
02

Publications

Scientific publications

  1. 01

    Lattice corneal dystrophy.

    Schmitt-Bernard CF, Claustres M, Arnaud B, Demaille J, Argiles A.

    Ophthalmology. 2000;107(9):1613–1614.
    PMID 10964807 ↗
  2. 02

    Antiproteases and cells in the pathogenesis of beta(2)-microglobulin amyloidosis: role of alpha(2)-macroglobulin and macrophages.

    Argilés A, Mourad G, Gouin-Charnet A, Schmitt-Bernard CF.

    Nephron. 2000;86(1):1–11.
    PMID 10971148 ↗
  3. 03

    [BIG-H3 protein: mutation of codon 124 and corneal amyloidosis].

    Schmitt-Bernard CF, Pouliquen Y, Argilès A.

    J Fr Ophtalmol. 2004;27(5):510–522.
    PMID 15179309 ↗
  4. 04

    [Factors of endothelial cell loss during phacoemulsification. Update].

    Schmitt-Bernard CF, Arnaud B.

    J Fr Ophtalmol. 1997;20(8):628–639.
    PMID 9515125 ↗
  5. 05

    Bicoronal incision for nasal bone grafting.

    Atlan G, Jammet P, Schmitt-Bernard CF, Dupoirieux L, Souyris F.

    Int J Oral Maxillofac Surg. 1994;23(1):2–5.
    PMID 8163854 ↗
  6. 06

    [Ocular toxocariasis. Value of local immunodiagnosis].

    Schneider C, Arnaud B, Schmitt-Bernard CF.

    J Fr Ophtalmol. 2000;23(10):1016–1019.
    PMID 11139695 ↗
  7. 07

    [Accuracy of videokeratographic quantitative criteria for detection of keratoconus suspects in families with keratoconus].

    Claude S, Verdier R, Arnaud B, Schmitt-Bernard CF.

    J Fr Ophtalmol. 2004;27(7):773–778.
    PMID 15499274 ↗
  8. 08

    BIGH3 exon 14 mutations lead to intermediate type I/IIIA of lattice corneal dystrophies.

    Schmitt-Bernard CF, Guittard C, Arnaud B, Demaille J, Argiles A, Claustres M, Tuffery-Giraud S.

    Invest Ophthalmol Vis Sci. 2000;41(6):1302–1308.
    PMID 10798644 ↗
  9. 09

    BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro.

    Schmitt-Bernard CF, Chavanieu A, Herrada G, Subra G, Arnaud B, Demaille JG, Calas B, Argilés A.

    Eur J Biochem. 2002;269(21):5149–5156.
    PMID 12392546 ↗
  10. 10

    Keratographic analysis of a family with keratoconus in identical twins.

    Schmitt-Bernard C, Schneider CD, Blanc D, Arnaud B.

    J Cataract Refract Surg. 2000;26(12):1830–1832.
    PMID 11134887 ↗
  11. 11

    [Molecular genetics of pigmentary retinopathies: identification of mutations in CHM, RDS, RHO, RPE65, USH2A and XLRS1 genes].

    Hamel CP, Griffoin JM, Bazalgette C, Lasquellec L, Duval PA, Bareil C, Beaufrère L, Bonnet S, Eliaou C, Marlhens F, Schmitt-Bernard CF, Tuffery S, Claustres M, Arnaud B.

    J Fr Ophtalmol. 2000;23(10):985–995.
    PMID 11139690 ↗
  12. 12

    Clinical, histopathologic, and ultrastructural characteristics of BIGH3(TGFBI) amyloid corneal dystrophies are supportive of the existence of a new type of LCD: the LCDi.

    Schmitt-Bernard CF, Schneider C, Argilés A.

    Cornea. 2002;21(5):463–468.
    PMID 12072720 ↗
  13. 13

    [Bilateral ocular blast injury after refractive surgery by 2 current techniques. Comparative anatomo-clinical analysis of a case].

    Schmitt-Bernard CF, Villain M, Beaufrere L, Arnaud B.

    J Fr Ophtalmol. 1996;19(4):287–291.
    PMID 8734223 ↗
  14. 14

    Accuracy of IRAS GT interferometer and potential acuity meter prediction of visual acuity after phacoemulsification: prospective comparative study.

    Le Sage C, Bazalgette C, Arnaud B, Schmitt-Bernard CF.

    J Cataract Refract Surg. 2002;28(1):131–138.
    PMID 11777722 ↗
  15. 15

    In vitro creation of amyloid fibrils from native and Arg124Cys mutated betaIGH3((110-131)) peptides, and its relevance for lattice corneal amyloid dystrophy type I.

    Schmitt-Bernard CF, Chavanieu A, Derancourt J, Arnaud B, Demaille JG, Calas B, Argiles A.

    Biochem Biophys Res Commun. 2000;273(2):649–653.
    PMID 10873659 ↗
  16. 16

    Keratectasia induced by laser in situ keratomileusis in keratoconus.

    Schmitt-Bernard CF, Lesage C, Arnaud B.

    J Refract Surg. 2000;16(3):368–370.
    PMID 10832988 ↗
  17. 17

    [Spontaneous hyphema caused by Ginkgo biloba extract].

    Schneider C, Bord C, Misse P, Arnaud B, Schmitt-Bernard CF.

    J Fr Ophtalmol. 2002;25(7):731–732.
    PMID 12399731 ↗
  18. 18

    [Clinical features and genetic analysis in a family with X-linked incomplete congenital stationary night blindness (CSNBi)].

    Schmitt-Bernard CF, Bareil C, Hamel CP, Beaufrere L, Arnaud B, Claustres M, de Meeus A.

    J Fr Ophtalmol. 1998;21(4):251–256.
    PMID 9759413 ↗
  19. 19

    [Clinically isolated Morning glory syndrome].

    Schneider C, Cayrol D, Arnaud B, Schmitt-Bernard CF.

    J Fr Ophtalmol. 2002;25(2):178–181.
    PMID 11941239 ↗
  20. 20

    [Ocular trauma and caustic burns by air bags].

    Schmitt-Bernard CF, Arnaud B.

    J Fr Ophtalmol. 1998;21(3):220–222.
    PMID 9759408 ↗
  21. 21

    Trauma after radial keratotomy and photorefractive keratectomy.

    Schmitt-Bernard CF, Villain M, Beaufrere L, Arnaud B.

    J Cataract Refract Surg. 1997;23(5):803–804.
    PMID 9278807 ↗
  22. 22

    Rat messenger RNA for the retinal pigment epithelium-specific protein RPE65 gradually accumulates in two weeks from late embryonic days.

    Manès G, Leducq R, Kucharczak J, Pagès A, Schmitt-Bernard CF, Hamel CP.

    FEBS Lett. 1998;423(2):133–137.
    PMID 9512345 ↗
  23. 23

    [Amiodarone and disk edema: physiopathological debate based on a case report].

    Aït Ali F, Grolleau-Raoux F, Arnaud B, Schmitt-Bernard CF.

    J Fr Ophtalmol. 2003;26(2):182–186.
    PMID 12660594 ↗
03

Presentations

Scientific presentations

SAFIR · Paris

Electron-imaging characterisation of implant-material degradation during combined phacoemulsification and endothelial-graft surgery.

CF Schmitt-Bernard, C Cazevieille.

SAFIR · Paris

Long-term follow-up and treatment of ectasia after refractive surgery.

CF Schmitt-Bernard.

POP Congress · Marseille

Can keratoconus be treated with the excimer laser?

CF Schmitt-Bernard.

CLVM Congress

Comparative assessment and outcomes of the Octavius system in refractive and therapeutic topography-guided treatments.

CF Schmitt-Bernard.

Conference · Narbonne

Lyophilised amniotic membrane grafts (AMTRIX, SCLERFIX) in ocular-surface reconstruction.

CF Schmitt-Bernard.

CLVM · Montpellier

Preliminary outcomes with Octavius software (Bausch + Lomb) in refractive surgery.

CF Schmitt-Bernard.

SAFIR · Paris

Perfect refraction, aberrations under control: does Octavius outperform Proscan?

CF Schmitt-Bernard, V Dieglio, M Barret.

SAFIR · Paris

Octavius for irregular astigmatism and keratoconus: a topography-guided approach to complex cases.

M Barret, CF Schmitt-Bernard.

OPHTA’NEWS · Nice

PRK + CXL: is there a measurable biomechanical benefit on Corvis ST?

CF Schmitt-Bernard.

Teaching, conferences and continuing education

Detailed teaching activities

Postgraduate programme “Corneal disease and contact lenses” · Montpellier

The event is listed as scheduled in the supplied CV.

Postgraduate teaching: corneal-tissue retrieval and preservation network in Languedoc-Roussillon · Montpellier University Hospital

Ophthalmology residency teaching · Montpellier Faculty of Medicine

Ophthalmology teaching for the Tropical Medicine Certificate

Ophthalmology teaching for the Montpellier orthoptics entrance course

Ophthalmology teaching at the School of Orthoptics

Undergraduate ophthalmology teaching and examination marking in 2000

Ophthalmology teaching for the University Diploma in Low Vision

Ophthalmology teaching at the School of Midwifery

In-house corneal-transplant training for ophthalmology-department staff

Continuing medical education for Mutualité sociale agricole physicians

Postgraduate teaching · Lattes Physicians’ Association

Postgraduate teaching: pain and corneal disease

Continuing medical education: specular microscopy · Nîmes University Hospital

Conference on transplantation and organ donation

Corneal-transplant conferences with the France ADOT association

Presentations in September 1997, April 1998 and December 2000.

Approximately 30 conferences on corneal disease and surgery

The CV does not provide the title, date and venue for each presentation, so they cannot be listed individually.